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 eosinophilia myalgia syndrome; Often lethal blood and muscle disorder reported in 1989 among people using supplements of the amino acid tryptophan, as a result of which tryptophan supplements were withdrawn in most countries. Subsequently shown to be associated mainly (or perhaps solely) with contamination of a single batch of tryptophan from one manufacturer with ethylidene bis-tryptophan, but doubts remain about the safety of tryptophan supplements.